表觀遺傳學(英文影印版•附贈CD)

表觀遺傳學(英文影印版•附贈CD)
定價:576
NT $ 501
 

內容簡介

表觀遺傳學是研究非DNA序列變化的、可遺傳的表達改變的科學,表觀遺傳達室學機制參與個體發育、成體的許多生物學進程中基因表達的調節,這一過程的異常可導致人類癌症和其他疾病的發生。本書是基礎研究專著,24章均由知名專家撰寫,分別從不同角度探討表觀遺傳學問題。首先介紹表觀遺傳學簡史、基本概念;然後詳細闡釋表觀遺傳調節的分子機制及與之相關的細胞生物學過程;介紹了組氨酸和DNA甲基化,siRNA和基因沉默,X染色體失活,劑量寂償和印記,以及微生物、植物、昆蟲和哺乳動物中的表觀遺傳機制;還討論了細胞分裂和分化中的表觀遺傳作用,以及這些途徑中發生的錯誤對癌症和人類腫瘤的影響;此外,也闡述了表觀遺傳在動物克隆中可能發生的影響。

本書可供發育生物學、細胞生物學、遺傳學、基因組學、神經生物學和分子生物學等生命科學相關領域的教學研究人員,以及本科生、研究生參考。
 

目錄

Preface
1 Epigenetics:From Phenomenon to Field
dANIEL e.gOTTSCHLING
2 a bRIEF hISTORY OF ePIGENETICS
Gary Felsenfeld
3 Overview and Concepts
C.David Allis,Thomas Jenuwein,and Danny Reinberg
4 Epigenetics in Saccharomyces cerevisiae
Michael Grunstein and Susan M.Gasser
5 Position-Effect Variegation,Heterochromation Formation,and Gene Silencing in Drosophila
Sarah C.R.Elgin and Gunter Reuter
6 Fungal Models for Epigenetic Research:Schizosac-charomyces pombe and Neurospora crassa
Robin C.Allshire and Eric U.Selker
7 Epigenetics of Ciliates
Eric Meyer and Douglas L.Chalker
8 RNAi and Heterochromatin Assembly
Robert Martienssen and Danesh Moazed
9 Epigenetic Regulation in Plants
Marjori Matzke and Ortrun Mittelsten Scheid
10 Chromation Modifications and Their Mechanism of Action
Tony Kouzarides and Shelley L.Berger
11 Transcriptional Silencing by Polycomb Group Proteins
Ueli Grossniklaus and Renato Paro
12 Transcriptional Regulation by Trithorax Group Proteins,
Robert E.Kingston and John W.Tamkun
13 Histone Variants and Epigenetics
Steven Henikoff and M.Mitchell Smith
14 Epigenetic Regulation of Chromosome lnheritance
Gary H.Karpen and R.Scott Hawley
15 Epigenetic Regulation of the X Chromosomes in C.elegans
Susan Strome and William G.Kelly
16 Dosage Compensation in Drosophila
John C.Lucchesi and Mitzi I.Kuroda
17 Dosage Compensation in Mammals
Neil Brockdorff and Bryan M.Turner
18 DNA Methylation in Mammals
En Li and Adrian Bird
19 Genomic lmprinting in Mammals
Denise P.Barlow and Marisa S.Bartolomei
20 Germ Line and Pluripotent Stem Cells
M.Azim Surani and Wolf Reik
21 Epigenetic Control of Lymphopoiesis
Meinrad Busslinger and Alexander Tarakhovsky
22 Nuclear Transplantation and the Reprogramming of the Genome
Rudolf Jaenisch and John Gurdon
23 Epigenetics and Human Disease
Huda Y.Zoghbi and Arthur L.Beaudet
24 Epigenetic Determinants of Cancer
Stephen B.Baylin and Peter A.Jones
Appendices
1 WWW Resources
2 Histone Modifications and References
lndex
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